4-Aminopyridine (4-AP) also known as Dalfampridine, Fampridine and Fampyra is used for the treatment of walking impairment in multiple sclerosis (MS). MS is estimated to affect more than 2.1 million people worldwide and is the most common disabling neurological disease in young adults (NMSS, 2010; Frohman, 2003). It has been available for the last 18 months through a number of channels all requiring a Doctors prescription.
Recently compounding pharmacies have been able to offer patients a more cost effective alternative than the proprietary brand. Please contact National Custom Compounding on 1300 731 755 and speak to our Pharmacists for more information.
Fampridine is indicated for symptomatic improvement of walking in adults with multiple sclerosis, including relapsing remitting, secondary progressive, relapsing and primary progressive. Currently there are no other drugs available for this indication.
Fampridine is thought to increase conduction in demyelinated nerves by inhibiting potassium channels. It can be used on its own or with other treatments for multiple sclerosis, including immunomodulatory drugs. This means that it can block the flow of ions in nerve cells, which results in a more effective nerve impulse traveling down toward the muscles. It has been studied most extensively in MS and other demyelinating neurological disorders, however its exact mechanism of action of this drug remains uncertain. 4-AP has been used for many years to treat symptoms associated with MS. The poor nerve impulses in patients with MS is the cause of most of the symptoms of the disease including visual deficits, weakness, numbness, paralysis and other sensory disturbances. (Compston and Coles, 2008; Smith and McDonald, 1999; McDonald, 1974), Weakness and fatigue are probably the most common problems people who suffer from Multiple Sclerosis (MS) face on a daily basis.
Before you take any medication inform your doctor and our pharmacists of any other medical conditions, including other prescription and non-prescription medicines, vitamins and herbal supplements. It is important that you understand and know your medications, keep a list of them and show it to your doctor and our Healthcare pharmacists prior to commencing any new medication. If in doubt please ask and we will explain your medications to you.
Before commencing treatment and or obtaining a repeat of 4-AP, we recommend you read this Consumer Medication Information (CMI). Please visit this page to download the information – Medicine Information.
We compound two versions of 4-A, an immediate release or standard release formulation and a slow/sustained release also known as controlled release capsules.
For both versions we recommend a staged dosing procedure, to allow the body to come a custom to the new medication we recommend that a single daily dose betaken for two to three days, then increase to two capsules daily.
Immediate Release. ( 5mg and 10mg capsules)
Slow Release (SR) or Controlled Release (CR) 10mg capsules
Note: Your doctor will decided on the strength.
- Goodman AD, Brown TR,Krupp LB, Schapiro RT, Schw
- Medscape http://www.medscape.com/viewarticle/742441