Pain is a very difficult and often chronic condition. Its source can be unknown, making diagnosis and treatment in some situations very difficult. Patients which suffer chronic pain may need to try a wide range of treatments, both medication and allied health, in an attempt to get the pain under control.
Recently I received a request from a Holistic Doctor in Brisbane to investigate a relatively new product called Palmitoylethanolamide (PEA). There has been a number of studies around this product and they have produced some good outcomes for Patients. (1).
Presentation of Product
Palmitoylethanolamide (PEA) is encapsulated by National Custom Compounding into 200mg or 400mg vegetable based capsules.
Currently this product is available as a ‘food’ product in Australia but we recommend that you see your doctor to ensure they correctly access your needs and review the available information.
Mode of Action
If you would like to learn more about PEA (Palmitoylethanolamide) please contact our Pharmacists on 1300731755 or email.
PEA is available without a prescription (unscheduled supplement) but we recommend that you consult with your Doctor first before commencing therapy.
Please CLICK HERE to download the full PEA study.
- Loeser Five crises in pain management. Pain Clin Updates. 2012;20: 1–4.
- Lo Verme J, Fu J, Astarita G, et al. The nuclear receptor peroxisome proliferator-activated receptor-alpha mediates the anti-inflammatory actions of palmitoylethanolamide. Mol Pharmacol. 2005;67:15–19.
- Darmani NA, Izzo AA, Degenhardt B, et al. Involvement of the can- nabimimetic compound, N-palmitoylethanolamine, in inflammatory and neuropathic conditions. A review of the available preclinical data and first human studies. Neuropharmacology. 2005;48:1154–1163.
- Genovese T, Esposito E, Mazzon E, et al. Effects of palmitoylethano- lamide on signaling pathways implicated in the development of spinal cord injury. J Pharmacol Exp Ther. 2008;326:12–23.
- Naderi N, Majidi M, Mousavi Z, Khoramian Tusi S, Mansouri Z. The interaction between intrathecal administration of low doses of palmi- toylethanolamide and AM251 in formalin-induced pain related behavior and spinal cord IL1-b expression in rats. Neurochem Res. 2012;37: 778–785.
- Yoshihara S, Morimoto H, Ohori M, Yamada Y, Abe T, Arisaka Cannabinoid receptor agonists inhibit Ca(2+) influx to synaptosomes from rat brain. Pharmacology. 2006;76:157–162.
- Ho WS, Barrett DA, Randall ‘Entourage’ effects of N-palmitoylethanolamide and N-oleoylethanolamide on vasorelaxation to anandamide occur through TRPV1 receptors. Br J Pharmacol. 2008;6: 837–846.
- Appendino G, Ligresti A, Minassi A, et al. Conformationally con- strained fatty acid ethanolamides as cannabinoid and vanilloid receptor probes. J Med Chem. 2009;52:3001–3009.
- Loría F, Petrosino S, Mestre L, et al. Study of the regulation of the endocannabinoid system in a virus model of multiple sclerosis reveals a therapeutic effect of Eur J Neurosci. 2008;28: 633–641.
- Esposito E, Paterniti I, Mazzon E, et al. Effects of palmitoylethanol- amide on release of mast cell peptidases and neurotrophic factors after spinal cord injury. Brain Behav Immun. 2011;25:1099–1112.
- Cerrato S, Brazis P, della Valle MF, Miolo A, Puigdemont A. Effects of palmitoylethanolamide on immunologically induced histamine, PGD2 and TNF-alpha release from canine skin mast Vet Immunol Immunopathol. 2010;133:9–15.
- De Filippis D, Luongo L, Cipriano M, et al. Palmitoylethanolamide reduces granuloma-induced hyperalgesia by modulation of mast cell activation in rats. Mol Pain. 2010;10:7:3
- Keppel Hesselink Glia as a new target for neuropathic pain, clinical proof of concept for palmitoylethanolamide, a glia modulator. Anesth Pain Intensive Care. 2011;15:143–145.
- Desio Combination of pregabalin and palmitoylethanolamide (PEA) for neuropathic pain treatment. Pathos. 2010;17:9–14.